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‘Combination approach’ of drug therapy and exercise reduces anxiety and depression after stroke in mouse model

Researchers at the University of Ottawa are studying the use of an anti-depressant drug called fluoxetine in combination with exercise to reduce anxiety and depression after stroke. More than a third of people who have a stroke experience depression and/or anxiety as a result of injury to their brains from stroke, which can worsen their outcome. Researchers have developed a unique mouse model to simulate post-stroke depression. Early results in the study funded by the HSF Canadian Partnership for Stroke Recovery show this combination approach helps reverse anxiety- and depression-like behaviours in the mouse model.

Principal investigators: Paul Albert and Diane Lagace with PhD candidate Faranak Vahid-Ansari

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