Stroke disability is a huge public health issue in Canada. While gains have been made in prevention and delivery of life-saving treatment, disability rates remain high for the 83 per cent of people who survive a stroke.
That’s why CPSR has developed a comprehensive research program to tackle all aspects of recovery. As an innovation hub, we have assembled the top scientists and clinicians in the field to advance discovery, test new findings and move research to clinical care.
CPSR describes the approach as “bedside to bench and back to bedside”. The needs of patients inform our research projects. Once discoveries are made, we work hard to move new findings back to patients as quickly as possible.
To support the work of all our researchers, the CPSR provides access to shared research platforms, including an Animal Stroke Model and Behaviour Testing Facility and a Preclinical Brain Imaging Facility at the University of Ottawa, a Human Brain Imaging Analysis Pipeline at Sunnybrook Health Sciences Centre, and a Stroke Rehabilitation Clinical Trial Infrastructure.
- Animal Stroke Model & Behaviour Testing and Preclinical Brain Imaging Facility
An animal behaviour core facility is available at the University of Ottawa. The facility has state-of-the-art automated equipment allowing for efficient and reproducible data collection. Novel animal models developed by the group include a mouse stroke model for photothrombosis, and a 7.0 Tesla MRI facility is available for high resolution imaging of stroke damage in animals.
- Human Brain Imaging Analysis Pipeline
Brain imaging analysis pipelines are important for stroke researchers trying to investigate brain-behaviour relationships in cross-sectional or longitudinal analyses. This platform, developed over the past 10 years, uses a standardized clinically practical imaging protocol to provide reliable and efficient quantifiable data of both structural and functional human brain damage to be used in analyses.
- Stroke Rehabilitation Clinical Trial Infrastructure
This platform was created to develop a network of partnerships (affiliations) with rehabilitation institutes to improve patient recruitment and expand capacity to implement translational studies. Future CPSR stroke rehabilitation clinical trials will be able to build upon infrastructure developed through this platform, including standardized assessment batteries, tablet-based data entry system, interprofessional relationships, as well as data mining natural stroke recovery profile data on more than 500 stroke patients.
For questions about CPSR platforms, including how to utilize these shared resources, please email Farrell Leibovitch, CPSR Director Research and Training Programs at firstname.lastname@example.org